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24Jan2026Select date
Check-out
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Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the Flame Run Glass Studio and Gallery

Amenities

21C Museum Hotel Louisville offers an impressive collection of contemporary art integrated throughout the hotel, including installations by renowned artists. The on-site 21C Museum includes a variety of exhibitions and a museum shop featuring unique artworks. Guests can enjoy exclusive access to the rooftop terrace providing sweeping views of the city.

Rooms

The hotel comprises 91 artfully designed guest rooms and suites, each equipped with curated art pieces to enhance the experience. Rooms offer spacious layouts with comfortable bedding and modern conveniences tailored for both leisure and business travelers. Some suites feature additional amenities such as separate living areas and city views.

Location

Located in downtown Louisville, 21C Museum Hotel places guests near attractions such as the Muhammad Ali Center and the Louisville Slugger Museum & Factory. The hotel is a short drive from the historic Kentucky Derby site, making it convenient for both sightseeing and cultural exploration. Visitors can take advantage of nearby dining, shopping, and entertainment options.

Dining

The hotel's in-house restaurant offers a menu that showcases locally sourced ingredients, creating hearty dishes that reflect the regional cuisine. Guests can unwind at the bar, which features a selection of handcrafted cocktails and beverages. Seasonal outdoor dining options are also available for those looking to enjoy meals al fresco.

Business Services

21C Museum Hotel offers over 7,000 square feet of flexible meeting and event space designed to accommodate various functions. The hotel provides modern audiovisual equipment and catering services to facilitate business gatherings. Personalized planning assistance ensures seamless execution for corporate events and meetings.

Highlights

Art: Contemporary art installations throughout the hotel

Location: Steps from Muhammad Ali Center and Slugger Museum

Dining: On-site restaurant with locally sourced ingredients

Meeting Space: Over 7,000 square feet of flexible space

Rooftop: Terrace with views of downtown Louisville

Uniqueness: Integration of art into every aspect of the hotel

Must-do experiences

  • Stop by the Big Four Bridge for stunning views of the river.
  • Try the Hot Brown at the Brown Hotel for a local culinary delight.
  • Visit the Muhammad Ali Center for a blend of culture and history.
  • Explore NuLu for unique shops and delicious local eateries.
  • Don't miss the Bourbon Trail for a taste of Kentucky's finest spirits.
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Amenities

Thoughtfully designed amenities for a comfortable & memorable stay

General

  • Wi-Fi in public areas
  • 24-hour reception
  • Wheelchair access

Services

  • Dry cleaning

Spa & Leisure

  • Sauna
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Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
800 ft
Museum
Muhammad Ali Center
1100 ft
Museum
Kentucky Science Center
600 ft
Museum
The Frazier History Museum
1200 ft
Museum
Kentucky Museum of Art and Craft
300 ft
528 W Main St
Evan Williams Bourbon Experience
700 ft
Gallery
Flame Run Glass Studio and Gallery
1000 ft
500 W Main St
The Belvedere
900 ft
Night club
Jimmy Can't Dance
200 ft
801 W Main St
Michter's Fort Nelson Distillery
500 ft
Library
Sons of the American Revolution Genealogical Research Library
700 ft
120 N 10th St
Kentucky Peerless Distilling Co
1600 ft
Restaurants
Luigi's Pizzeria
300 ft
712 W Main St
Main Eatery
200 ft
643 W Main St
Boomers
400 ft
722 W Main St
Subway
500 ft
725 W Main St
Spinelli's Pizzeria
1800 ft
614 Baxter Ave Ste 4
Cravings Ala Carte
1400 ft
101 S 5th St Ste LL100
Spinellis Pizza
1800 ft
239 South 5th Street
Bazo's Fresh Mexican Grill
1600 ft
428 W Market St Located in Louisville's Central Business District.
Sunergos Coffee
1800 ft
231 S 5th St Located in Louisville's Central Business District.
Thelma's Deli
1700 ft
104 N 4th St Galt House
Jimmy John's
2100 ft
301 E Market St Unit 101
Explore Louisville
Explore Nearby Activities and Dining
Top Attractions
Activities
Dining
Entertainment
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes' walk
Interactive exhibits on baseball history and factory tours where bats are made. A must-see for sports enthusiasts.
Muhammad Ali Center
Muhammad Ali Center
4 minutes' walk
Cultural center dedicated to the life of boxer Muhammad Ali. Features exhibits on social justice and peace.
Kentucky Science Center
Kentucky Science Center
2 minutes' walk
Hands-on science exhibits and an IMAX theater, perfect for families and curious minds of all ages.
The Frazier History Museum
The Frazier History Museum
5 minutes' walk
Showcases Kentucky's history through interactive exhibits and artifacts, including bourbon and civil rights themes.
Waterfront Park
Waterfront Park
20 minutes' walk
A scenic space with walking trails and picnic areas beside the Ohio River. Great for relaxation and outdoor fun.
Angel's Envy Distillery Tour
20 minutes' walk
Tour the distillery to learn about bourbon production with tastings included. Reservations are recommended.
Luigi's Pizzeria
Luigi's Pizzeria
2 minutes' walk
Casual eatery known for its authentic pizzas and pasta. A favorite among locals-try the Margherita!
Main Eatery
Main Eatery
1 minute' walk
Cozy spot featuring local dishes with a modern twist. Ideal for brunch or quick bites anytime.
Fourth Street Live!
11 minutes' walk
Vibrant entertainment district with live music, bars, and dining options, hosting events year-round.
Belle of Louisville Riverboats
Belle of Louisville Riverboats
10 minutes' walk
Cruise along the Ohio River with sightseeing and themed entertainment. Family-friendly with a classic atmosphere.
Getting around
City Centre
Louisville23 min  ·  1.2 mi
Airports
Louisville International Airport (SDF)15 min  ·  6.2 mi
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Number of floors:
4
Number of rooms:
91
Check-in
24Jan2026Select date
Check-out
25Jan2026Select date
Rooms and Guests2 Guests, 1 Room
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